Voltaren 12H Gel contains the non-steroidal anti-inflammatory drug (NSAID) diclofenac, which is designed to target delivery of pain-relieving and anti-inflammatory relief directly to the affected underlying tissue. This highly concentrated gel has double the concentration of diclofenac diethylamine than Voltaren Emulgel, and is able to penetrate deeper into the skin than other topical options such as cooling gels and heat patches, which only act physically on the outer surface of the skin.